Influenza Virus Mashup

Influenza Virus Mashup

Archive for April, 2010

[Crof's H5N1] Argentina: 3.6 million immunized against H1N1

Posted by Automator On April - 24 - 2010

Via Clarín.com: Ya se vacunaron 3,6 millones de argentinos contra la Gripe A.[3.6 million now vaccinated against H1N1] Excerpt, with my translation:

Ya 3,6 millones de argentinos recibieron gratis la vacuna monovalente contra la gripe A H1N1, según dijo ayer el titular de la cartera de salud del Gobierno, Juan Manzur. Espera llegar a vacunar al 20 % de la población, que es la que se encuentra en mayor riesgo de sufrir complicaciones por la gripe.

Health Minister Juan Manzur said yesterday that 3.6 million Argentines have received free vaccinations against H1N1 flu. He hopes to vaccinate the 20% of the population at greatest risk of suffering complications from flu.

[Avian Flu Diary] An Unexpected Dividend

Posted by Automator On April - 24 - 2010

(Sat, 24 Apr 2010 13:05:00 +0000)

 

 

# 4522

 

 

Long ago, and in a galaxy far, far away . . . I was part of a national effort to immunize the country against a feared swine flu pandemic.  The year was 1976, and after a disastrous vaccination campaign that saw 40 million Americans get vaccinated, the pandemic (thankfully) never materialized.

 

I’ve written about those events several times, including Deja Flu, All Over Again.

 

 

Now it seems that the much-maligned swine flu vaccination of 1976 may be responsible for an enhanced immune response in some individuals against the 2009 novel H1N1 virus.

 

This press release from St. Jude Children’s Research Hospital.

 

Study Links 1976 ‘Swine Flu’ Shot to Stronger Immune Response to 21st Century Pandemic Flu

St. Jude Children’s Research Hospital staff helps investigators gauge the lingering impact of the 1976 vaccine

MEMPHIS, Tenn., April 23 /PRNewswire-USNewswire/ — New evidence shows immunization against “swine flu” in 1976 might provide individuals with some protection against the 2009 pandemic H1N1 influenza virus, according to new research from St. Jude investigators.

 

Researchers found that individuals who reported receiving the 1976 vaccine mounted an enhanced immune response against both the 2009 pandemic H1N1 virus and a different H1N1 flu strain that circulated during the 2008-09 flu season. The work appears in the April 23 online issue of the journal Clinical Infectious Diseases.

 

“Our research shows that while immunity among those vaccinated in 1976 has waned somewhat, they mounted a much stronger immune response against the current pandemic H1N1 strain than others who did not receive the 1976 vaccine,” said Jonathan A. McCullers, M.D., an associate member of the St. Jude Infectious Diseases Department and the study’s lead author.

 

McCullers said it is unclear if the response was enough to protect against the 2009 H1N1 virus, but the study points to a lingering benefit. The findings also raise hope that those vaccinated against the 2009 H1N1 pandemic strain might also enjoy a similar long-term advantage.

(Continue . . . )

[Avian Flu Diary] CIDRAP: H1N1 Lessons Learned

Posted by Automator On April - 24 - 2010

(Sat, 24 Apr 2010 11:43:00 +0000)

 

 

 

# 4521

 

 

Last night CIDRAP (The Center For Infectious Disease Research And Policy) published what they promise will be the first in a series of special reports on lessons learned from the H1N1 pandemic. 

 

Penned by News Editor Robert Roos, this first installment covers a lot of territory, and it well worth your time to read.

 

CIDRAP also maintains some of the best - and most up-to-date - information on the H1N1 pandemic in their overview entitled Novel H1N1 Influenza (Swine Flu).  

 

This is a resource I turn to often.

 

Robert Roos interviews Columbia Virology Professor Vincent Racaniello, Dan Jernigan of the CDC’s Influenza Division, chair of the Department of Preventive Medicine at Vanderbilt University, William Schaffner, MD, chair of IDSA’s pandemic flu task force Andrew Pravia, M.D., and Associate Professor of Medicine and chair of ACIP’s influenza working group Kathleen M. Neuzil, MD, MPH for this piece.

Some of the topics addressed include:

 

Geographic expectations

Wave pattern

Impact on the population

Health system stressed

The clinical picture

Obesity emerges as risk factor

Danger for pregnant women

Other lessons learned

Outlook for next season

Highly recommended. 

 

I’ll just reproduce the opening to the CIDRAP article.  Follow the link to read it in its entirety.

 

 

H1N1 LESSONS LEARNED

Pandemic underscored influenza’s unpredictability

Robert Roos * News Editor

Editor’s Note: This is the first of a series of articles reviewing the world’s experience with pandemic H1N1 influenza and what we’ve learned in the past year. Look for further installments in the days to come.

 

Apr 23, 2010 (CIDRAP News) – A year’s experience with the 2009 H1N1 influenza virus has underscored the endless unpredictability of flu.

 

The virus and the resulting illness defied expectations on many levels. It was first detected in North America, not Southeast Asia. Unlike the pathogens that caused previous pandemics, the virus was not a new subtype, but rather an H1N1 strain, making it a cousin of a seasonal flu strain that’s been around for decades.

 

Unlike seasonal flu, though, the illness hit children and nonelderly adults much more than people over 65. It was relatively mild for most people, unlike the 1918 flu or the devastating disease associated with H5N1 avian flu, which had heavily shaped pandemic preparations. But it killed far more children and young people than seasonal flu typically does, with the vast majority of deaths involving people younger than 60.

(Continue . . .)

[Crof's H5N1] WHO: Update 97

Posted by Automator On April - 24 - 2010

WHO has published Pandemic (H1N1) 2009 - update 97. Excerpt:

As of 18 April 2010, worldwide more than 214 countries and overseas territories or communities have reported laboratory confirmed cases of pandemic influenza H1N1 2009, including over 17853 deaths. 

WHO is actively monitoring the progress of the pandemic through frequent consultations with the WHO Regional Offices and member states and through monitoring of multiple sources of information. 

Situation update: 

Summary: Currently the most active areas of transmission of pandemic influenza are in parts of West and Central Africa but transmission is also still occurring in South East Asia, and Central America. Pandemic influenza activity remains low in much of the temperate zone of both the northern and southern hemispheres. Seasonal influenza type B viruses have been increasingly detected over a larger area and are now the predominant circulating influenza viruses across East Asia, Central Africa and Northern and Eastern Europe. Very small numbers of type B viruses have also recently been detected in Central America. Seasonal influenza H3N2 is still being detected in South and Southeast Asia (mainly Indonesia), as well as sporadically in several countries of West Africa, and Eastern Europe.

[Crof's H5N1] Spain: "The second and third years are the worst"

Posted by Automator On April - 24 - 2010

Via La Voz de Galicia.es: Los expertos advierten de un nuevo y peor brote de gripe A. [Experts warn of a new and worse outbreak of H1N1] Excerpt, with my translation:

Generó una gran alarma social, pero al final no ha sido para tanto. Un total de 300 personas han fallecido en todo el país desde que hace un año se declaró la pandemia de la gripe A. Además, otras 4.000 enfermaron de gravedad y cerca de mil fueron ingresadas en unidades de cuidados intensivos, según los datos del Ministerio de Sanidad y Consumo. 

It created a huge social alarm, but in the end it wasn’t much. A total of 300 persons have died in the country in the year since H1N1 was declared a pandemic. As well, another 4,000 persons fell gravely ill, and almost 1,000 went into intensive care, according to the Ministry of Health.

Estas cifras contrastan con las más de 8.000 muertes que provocó la gripe estacional durante el mismo período y las más de 76.000 hospitalizaciones. Pero no hay que bajar la guardia, porque el virus volverá y será más mortífero. 

These numbers contrast with the more than 8,000 deaths caused by seasonal flu during the same period, along with over 76,000 hospitalizations. But we shouldn’t drop our guard, because the virus will come back, and it will be deadlier.

Eso advirtió ayer el investigador británico John Oxford, una de las máximas autoridades mundiales en virología, que ofreció la conferencia inaugural del simposio sobre la gestión de las gripes en el siglo XXI, organizado por la empresa Esteve y que reunió en el parador de Baiona a más de 200 especialistas. La pandemia pudo haber sido más importante, pero se contuvo de una manera eficaz. «Lo peor no es el primer año, sino el segundo y el tercero», aseguró este especialista. «Hay que vacunarse. Frenar la pandemia también es una cuestión de responsabilidad personal», dijo.

This was the warning of the British expert John Oxford, one of the major world authorities in virology, who spoke to the inaugural conference of a symposium on 21st-century influenzas, organized by Esteve and which brought over 200 specialists together in Baiona. The pandemic could have been worse, but it was dealt with effectively. “The worst isn’t in the first year, but in the second and third,” said this specialist. “People must get vaccinated. Stopping the pandemic is also a question of personal responsibility.”

[Flu Wiki Forum] News Reports for April 24, 2010

Posted by Automator On April - 24 - 2010

(Sat, 24 Apr 2010 02:09:36 GMT)

Reminder: Please do not post whole articles, just snippets and links. Thanks!!

Australia

?  Flu jab fears grow as toddlers rushed to hospital (Link)

India

?  Swine flu case reported (Link)

United States

?  US: H1N1 vaccine study investigating hints of complications from vaccine (Link)

?  HI: Mild outbreak of swine flu reported on Maui (Link)

Vietnam

?  Three tons of smuggled chicken destroyed (Link)

Research

?  Study links 1976 ’swine flu’ shot to stronger immune response to 21st century pandemic flu (Link)

Commentary

?  Recombinomics: US Pneumonia & Influenza Deaths Spike To Epidemic Threshold (Link)

?  CIDRAP: H1N1 Lessons Learned (Link)



?  H (Link)

News for April 23, 2010 is here.

US Influenza-Like Illness Reports
Week ending Apr. 17, 2010


Thanks to all of the newshounds!
Special thanks to the newshound volunteers who translate international stories - thanks for keeping us all informed!

Other useful links:

CDC A(H1N1) Site

WHO A(H1N1) Site

WHO H5N1 human case totals, last updated April 21, 2010
Charts and Graphs on H5N1 from WHO
Google Flu Trends (U.S.)
CDC Weekly Influenza Summary
Map of seasonal influenza in the U.S.
CIDPC (Canada) Weekly FluWatch
European CDC Influenza News
UK RCGP Weekly Data on Communicable and Respiratory Diseases
Flu Wiki Main Page

[Crof's H5N1] Mexico: One year later

Posted by Automator On April - 23 - 2010

Via CTV News, a report from The Associated Press: One year after swine flu, Mexicans split on response. Excerpt:

Within five days of last year’s April 23 flu announcement, Mexico City would essentially shut down, streets empty of traffic and almost every business shuttered by government order. Only a few wary, masked silhouettes plied the streets, and a pall of fear and mistrust settled over the city. 

One year later, the fear is gone but Mexico still is feeling the human and economic consequences of swine flu. 

The pandemic killed 1,185 people in Mexico — out of 17,700 deaths worldwide. Tourism revenues, Mexico’s largest source of income after oil and remittances, have yet to recover to pre-flu levels. 

Lezana estimates that about half of Mexico’s 107 million people have immunity to the virus, either through the vaccine or contracting a mild case of swine flu, giving the country a “herd immunity” that would slow the transmission chain of the H1N1 virus. 

But Mexico, like many other nations, is still struggling to give out increasingly unpopular vaccines. About three-quarters of the way to fulfilling the nation’s goal of 30 million vaccinations, many here wonder why they should risk the shot’s real or imagined side effects at this point.

Thanks to the reader who sent the link to this report in The AustralianDoctors told to stop giving flu vaccine to children under five. Excerpt:

Doctors have been told to stop giving the seasonal flu vaccine to children under five amid a serious health scare in Western Australia. 

Australia’s chief medical officer Jim Bishop has issued the advice this morning. 

“We suggest doctors and health professionals vaccinating children don’t use the seasonal flu vaccine for the moment, until we can get the Therapeutic Goods Administration to investigate this in more detail,” Dr Bishop told ABC TV. 

At least one child has become seriously ill and about 45 suffered serious adverse reactions after receiving the free vaccine in WA in the past month. 

“I’m advising all doctors today not to use it until we know a bit more,” Professor Bishop said.

Top News has a follow-up story: Tasmania also suspended flu shots for children. And Medical News Today has a good, detailed report. Mike Coston at Avian Flu Diary has some excellent comment.

[Avian Flu Diary] Shakes On A Plane

Posted by Automator On April - 23 - 2010

(Fri, 23 Apr 2010 13:26:00 +0000)

 

 

# 4520

 

 

 

A couple of news reports in USA Today, and a relevant blog post from Jimmy Jazz at Break Glass  (see Quickly Noted: Proposed Quarantine Regulations Dropped), highlight the difficulties involved in trying to keep potentially infectious individuals from boarding commercial airline flights.

 

 

 

The video above, which as been making the rounds for a couple of years, was made by ZHAW (Zürcher Hochschule für Angewandte Wissenschaften) or The Zurich University of Applied Sciences.

 

It is a simulation (using real data) showing 24 hours of air traffic around the world. 

 

Every year there are more than 17,000,000 commercial airline flights (data from year 2000 - it’s probably higher now) that carry hundreds of millions of passengers each year.  

 

And on any given day, some percentage of those passengers are likely to be infected with potentially communicable diseases. And not all of them will be symptomatic.

 

During the initial outbreak of novel H1N, there were demands by many that authorities try to identify and interdict sick passengers in the hope of preventing the spread of the virus. 

 

But as many predicted, and as events later proved, doing so was nigh on impossible.

 

Last June, in Vietnam Discovers Passengers Beating Thermal Scanners, we learned that many passengers were taking Tylenol and other fever reducers prior to flying simply so they would not be detected by thermal scanners and detained.

 

And even before the pandemic outbreak began, we saw studies that questioned the effectiveness of airport screening for pandemic flu, such as Can Island Nations Effectively Quarantine Against Pandemic Flu? and Study: U.S. Airport Entry Screening In Response To Pandemic Influenza.

 

Roughly three weeks ago it was quietly announced that the Obama administration was going to drop sweeping quarantine regulations that the CDC had promoted back in 2006.

 

Obama administration scraps quarantine regulations

Posted 4/1/2010 8:53 PM |

By Alison Young, USA TODAY

The Obama administration has quietly scrapped plans to enact sweeping new federal quarantine regulations that the Centers for Disease Control and Prevention touted four years ago as critical to protecting Americans from dangerous diseases spread by travelers.

 

The regulations, proposed in 2005 during the Bush administration amid fears of avian flu, would have given the federal government additional powers to detain sick airline passengers and those exposed to certain diseases. They also would have expanded requirements for airlines to report ill passengers to the CDC and mandated that airlines collect and maintain contact information for fliers in case they later needed to be traced as part of an investigation into an outbreak.

(Continue . .. )

 

The CDC and the HHS are said to be drafting new recommendations based on lessons learned since those proposals were made.

 

In a related report from yesterday, we learn that the reporting requirements currently in place are apparently not identifying all those who fall ill (or even die) on airline flights in the United States.

 

Review: Many sick airline passengers aren’t reported

  • By Alison Young, USA TODAY

Hundreds of people at major U.S. airports each year are severely ill with symptoms of potentially contagious diseases, yet few are reported to health officials as intended under U.S. regulations and international guidelines, a USA TODAY review of ambulance records and federal data shows.

 

To detect diseases such as pandemic flu, tuberculosis and measles, federal regulations require airlines to notify health officials of passenger illnesses involving diarrhea or fever plus rash, swollen glands or jaundice. The International Civil Aviation Organization, a United Nations agency, also includes persistent vomiting or coughing in its guidelines.

(Continue . . . )

 

 

Obviously nobody would choose to be seated next to someone shaking with chills, a fever, vomiting, diarrhea, or other such symptoms.  And identifying sick passengers, and following up to see if they presented some sort of a public health threat, makes sense.

 

But the simple truth is that unless you are a hermit, you probably come in daily contact with people carrying all manner of potentially infectious diseases.

Rhinoviruses, adenoviruses, noroviruses, influenza  and even more serious pathogens like Tuberculosis.

 

Some of those people will be symptomatic, while others won’t appear to be ill at all. 

 

No screening process is going to catch them all. And no reporting system is going to identify every sick passenger for CDC follow up.

 

While I wish I could be more optimistic about such interventions, I’m resigned to the fact that whatever is devised is going to be an imperfect solution.

(Fri, 23 Apr 2010 10:20:00 +0000)

 

 UPDATED

# 4519

 

 

The safety of the swine flu vaccine has been a volatile topic for nearly a year now, with anti-vaccine activists issuing dire warnings on the subject as early as last summer . . .  months before the first doses rolled off the manufacturer’s fill and finish line.

 

After having tens of millions of doses swine flu vaccine delivered into arms around the world, it is abundantly clear that the safety profile of the pandemic vaccine is comparable with flu vaccines of the past.

 

In other words, it’s pretty darn safe.

 

Which isn’t to say it is 100% safe.   No vaccine can make that claim. Rare side effects do occur.  And sometimes those side effects can be serious.

 

Of course, there are thousands of deaths and serious side effects each year attributed to the use of over-the-counter medicines like aspirin and Tylenol as well.

 

There is no such thing as a completely safe drug.

 

In November of last year, Canadian officials recalled a batch of GSK H1N1 vaccine that was linked to an increased incidence of anaphylactic reactions (see Branswell Reports On GSK Vaccine Allergic Reactions).

 

And the VAERS (Vaccine Adverse Event Reporting System) has recorded several thousand adverse side effects in the United States, although most (93%) have been classified as `non-serious’. 

 

A few blogs on the swine flu vaccine safety record to date include:

 

What A Difference Three Decades Makes
CIDRAP Reports On H1N1 Vaccine Safety
Canada Probes Adverse Vaccine Reactions
MMWR Vaccine Safety Report
VAERS Vaccine Safety Report
The Background Is Always In Motion

 

Today, however, we learn of 60 young children in Australia who have apparently had a pyrogenic (fever) reaction to the new trivalent vaccine being rolled out in advance of their impending flu season.

 

Unlike the monovalent pandemic jab given last fall, this vaccine incorporates antigens to protect against three flu strains; A/California/7/2009 (H1N1); A/Perth/16/2009-like virus(H3N2); and B/Brisbane/60/2008-like virus.

 

Authorities have called for the temporary suspension of flu shots for children under the age of 5 until the cause can be identified.

 

This from the Sydney Morning Herald.

 

Fevers in 60 children linked to flu vaccine

April 23, 2010 - 4:42PM

    More than 60 West Australian children may have had adverse reactions to the flu vaccine, the state’s health department says.

     

    West Australian Health Minister Kim Hames announced yesterday that vaccinations for children under the age of five would be halted after a number of reactions to the three-strain vaccine, which includes swine flu.

     

    Australia’s chief medical officer Jim Bishop today said health professionals nationwide should immediately stop immunising children under five with the vaccine, as a precaution.

     

    West Australian Health Department chief health officer Tarun Weeramanthri said a higher-than-expected number of reactions to the vaccine, which is offered free by the state government to children under five, had been reported.

     

    The Princess Margaret children’s hospital (PMH) had reported 44 children under 10 had presented with febrile convulsions, of which 23 related to the paediatric flu vaccine.

     

    Of the 23 children, 12 were admitted to hospital.

     

      

    (Continue . . . )

     

     

    Since there are a number of possibilities here, I’ll not attempt to speculate as to the cause of these adverse reactions. 

     

    When more information becomes available, however, I’ll pass it on.

     

     

    UPDATED 0655 EDT

     

    While I was putting together this blog entry, Sally Furniss – Managing Editor at FluTrackers, was posting a series of articles out of New Zealand which indicate that children there may have been adversely affected by the vaccine as well.

     

    Children suffer serious reactions to flu vaccine

    Updated at 9:25pm on 23 April 2010

    Some New Zealand children have suffered serious adverse reactions after being given a seasonal flu vaccine.

    The Ministry of Health says it has received reports that four children in New Zealand have been seriously affected after being given Fluvax.

    (Continue . . . )

    Flu vaccine linked to convulsions in children

    Fri, 23 Apr 2010 8:53p.m.

    Doctors in New Zealand have been advised against using the influenza vaccine Fluvax on children following reports in Australia of some cases of convulsions soon after jabs.

    Australia’s chief medical officer gave the same advice to doctors in that country following concerns stemming from a significant rise in the number of children developing a fever after receiving the vaccine.

    Western Australian Health Minister Kim Hames yesterday suspended the state’s free flu vaccination programme for children under five after some recipients went into a febrile convulsion - a fit caused by a high temperature.

    (Continue . . . )

     

     

    Obviously, this is a story we will continue to follow.